Tesamorelin, CJC-1295 blend, the research
The research on the blend has been extensive and promising. Here are some key findings from several studies:
In Vitro Metabolism and Detection: Studies have investigated the in vitro metabolism and detection of Tesamorelin and CJC-1295, among other GHRH synthetic analogues. This research is crucial for understanding how these substances are processed in the body and how they can be detected, which is particularly important for anti-doping efforts in sports.
Reduction of Abdominal Fat: Clinical trials found that Tesamorelin can reduce fat accumulated around the waistline. This aligns with Tesamorelin's FDA-approved use for reducing abdominal fat in HIV-infected patients with lipodystrophy.
GH/IGF-1 Axis Activation: A study designed to identify GH and/or IGF-1 action biomarkers in serum samples found that CJC-1295 activates this axis. The GH/IGF-1 axis refers to the interaction between (IGF-1) which is an insulin-like growth factor 1 and growth hormone (GH), which play key roles in growth and metabolism.
Motor Skills Enhancement in Stroke Patients: Growth hormone therapy has been found to enhance motor skills in stroke patients. While not specifically about Tesamorelin or CJC-1295, this finding suggests potential therapeutic applications for these and other substances that stimulate GH release.
Potent Stimulation of GH Secretion: Research indicates that the combination of Tesamorelin, CJC-1295, and Ipamorelin acts as a potent stimulator of GH secretion, similar to GHRH8. This could potentially lead to a range of benefits associated with increased GH levels, such as increased muscle growth and improved fat loss.
How does this blend work?
Tesamorelin and CJC-1295, when used together, function as potent stimulators of natural growth hormone production.
Tesamorelin: When introduced into the body, tesamorelin mimics the effects of natural GHRH. It binds to receptors on cells in the pituitary gland, signaling them to increase the production and release of growth hormone (GH).
CJC-1295: This is another synthetic peptide that also functions like GHRH. However, it has been modified to last longer in the body. The molecule includes a Drug Affinity Complex (DAC), which slows its breakdown. As a result, CJC-1295 can provide a steady, long-term stimulation of the pituitary gland to produce GH.
When these two peptides are combined, they can create a more potent and sustained release of GH than either one could achieve alone. The short-term, intense GH release triggered by tesamorelin is complemented by the longer-lasting, steadier GH release stimulated by CJC-1295. This can lead to a greater overall increase in GH levels, providing various health benefits, including increased muscle growth, improved fat loss, better sleep, and improved recovery from injury.
What are the benefits of Tesamorelin, CJC-1295 blend?
The combination of Tesamorelin and CJC-1295 can offer a range of potential benefits linked to the increased production and release of growth hormone.
Promotion of Lean Muscle Mass: Both Tesamorelin and CJC-1295 can stimulate the growth of lean muscle mass, as growth hormone plays a crucial role in the growth and repair of muscle tissue.
Reduction of Body Fat: These peptides can also help decrease body fat percentage. Growth hormone promotes the breakdown of fat (lipolysis) and inhibits its accumulation.
Improved Sleep: Growth hormone is released in pulses during sleep, particularly during deep sleep. The blend of Tesamorelin and CJC-1295 might improve sleep quality by boosting GH levels.
Enhanced Recovery and Healing: Increased growth hormone levels can aid in faster recovery from injury and intense workouts by promoting tissue repair. It can also contribute to improved joint and connective tissue health.
Reduction of Visceral Adipose Tissue (VAT): Tesamorelin has been shown to reduce VAT, the fat stored in the abdominal area around the internal organs.
Boosted Cognitive Functioning: Some studies suggest that Tesamorelin can improve cognitive function.
Sources:
https://pubmed.ncbi.nlm.nih.gov/16352683/
https://pubmed.ncbi.nlm.nih.gov/19386527/
https://academic.oup.com/jcem/article/91/12/4792/2656274?login=false
https://pubmed.ncbi.nlm.nih.gov/34665524/
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/dta.3183
https://www.sciencedirect.com/science/article/abs/pii/S1096637409000409