Decapeptide-12 200mg

Decapeptide-12 Research Application

Research into Decapeptide-12 has shown promising results in several applications:

• Skin Brightening: Studies have evaluated the efficacy Decapeptide-12 in skin brightening systems, often in combination with other ingredients like glycolic acid. The findings suggest that these systems may effectively treat conditions like facial melasma.
• Topical Delivery: Research has also explored the best methods for delivering Decapeptide-12 to the skin. One study found that using microneedles could enhance the permeation of the peptide.
• Anti-senescence Activity: Some research suggests that Decapeptide-12 might have anti-senescence activity, potentially improving overall skin appearance.
• Post-peeling Care for Melasma Treatment: A study showed that a blend of bleaching products, including Decapeptide-12, can effectively post-peeling care for melasma treatment.

Decapeptide-12 Structure

• Sequence: Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr
• Molecular Formula: C65H90N18O17
• Molecular Weight: 1395.3 g/mole

What is Decapeptide-12?

Decapeptide-12 is a synthetic peptide used in skincare for its ability to reduce hyperpigmentation. It inhibits melanin production, the pigment responsible for skin color, thereby brightening the skin. It's considered safer than traditional skin-lightening ingredients like hydroquinone.

What Does Decapeptide-12 Do?

Decapeptide-12 is a competitive inhibitor of tyrosinase, an enzyme responsible for melanin production, the pigment that gives skin its color. It works by reversibly binding to tyrosinase in pigment-producing cells, inhibiting its activity and reducing melanin synthesis.

This process leads to the lightening of skin tone. In fact, studies have shown that Decapeptide-12 is nearly 17 times more potent as a tyrosinase inhibitor than hydroquinone, a commonly used skin-lightening agent.

Moreover, unlike hydroquinone, Decapeptide-12 does not cause adverse effects when used for skin-lightening purposes. Its ability to restrain tyrosinase effectively helps treat conditions such as hyperpigmentation, where there is excessive melanin production, leading to patchy pigmentation.

Decapeptide-12 and Lightening of Skin Tone Research

Decapeptide-12 is a synthetic peptide that has been studied extensively for its role in skin lightening by inhibiting melanin production. It works by competitively inhibiting the enzyme tyrosinase, which is involved in melanin synthesis. A study found it to be effective in treating facial melasma, with one patient showing complete success.

Another study demonstrated the enhanced skin retention and permeation of Decapeptide-12 through structural modification, chemical enhancement, and microneedles.

Furthermore, an emulsion containing 0.01% decapeptide-12 was evaluated in a pilot study for its efficacy, supporting its use in skin-lightening products.

Sources: 

https://www.researchgate.net/profile/Sandra-Ramirez-17/publication/248384382_Open-label_evaluation_of_a_novel_skin_brightening_system_containing_001_decapeptide-12_in_combination_with_20_buffered_glycolic_Acid_for_the_treatment_of_mild_to_moderate_facial_melasma/links/5fdb6392a6fdccdcb8d3c665/Open-label-evaluation-of-a-novel-skin-brightening-system-containing-001-decapeptide-12-in-combination-with-20-buffered-glycolic-Acid-for-the-treatment-of-mild-to-moderate-facial-melasma.pdf?_sg%5B0%5D=started_experiment_milestone&origin=journalDetail

https://www.biorxiv.org/content/10.1101/2020.10.07.312850v1.abstract

https://norcaloa.com/journals/DERM/DERM-101018.pdf

https://www.redalyc.org/journal/2655/265568335010/265568335010_2.pdf

https://jddonline.com/articles/combined-topical-delivery-and-dermalinfusion-of-decapeptide-12-accelerates-resolution-of-post-inflam-S1545961614P0084X

https://pdfs.semanticscholar.org/a125/3f25774f6a53e7140698ef5785d648d42057.pdf

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0625.2012.01528.x

https://www.sciencedirect.com/science/article/abs/pii/S0378517321006736