CJC-1295 is a powerful peptide known for stimulating growth hormone production (GH). As a synthetic analogue of growth-hormone-releasing hormone (GHRH), it plays a vital role in developing muscle mass, increasing fat loss, and efficient synthesis of protein in the body. This peptide is often combined with Ipamorelin, another peptide that also stimulates the release of GH.
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CJC-1295 is a lab-made peptide that encourages the release of growth hormone (GH). It was developed as a long-acting version of growth hormone-releasing hormone (GHRH) to maintain steady levels of GH in the bloodstream over an extended period.
The peptide comprises 29 amino acids, mirroring the natural GHRH released in the brain's hypothalamus. CJC-1295 binds to receptors on pituitary cells to stimulate the production and release of GH into the bloodstream.
The benefits associated with CJC-1295 are primarily linked to increased GH and include enhanced muscle growth, improved fat loss, and better protein synthesis. It can also contribute to improved sleep, increased cellular repair, and enhanced performance and recovery.
CJC-1295 and CJC-1295 DAC are variants of the same peptide that stimulate growth hormone release. The primary difference lies in their half-lives and the duration of their effects due to the presence or absence of the Drug Affinity Complex (DAC).
CJC-1295 without DAC has a significantly shorter half-life, approximately 30 minutes. This version promotes a pulsatile release of growth hormone, mimicking the body's natural secretion pattern.
On the other hand, CJC-1295 with DAC, also known as DAC: GRF, includes an extra molecule at the end of the peptide chain, the Drug Affinity Complex. This modification allows the peptide to bind to albumin in the bloodstream, prolonging its half-life by up to 8 days. As a result, it elevates growth hormone levels for a more extended period, which is not typical of the body's natural rhythm.
Deciding between CJC-1295 and CJC-1295 DAC would depend on the individual's specific goals and health situation.
Half-life of CJC-1295-DAC compared to standard growth hormone releasing factor (GRF)
Source: Oxford Academic
Initially, ConjuChem Biotechnologies, the developer of DAC, labeled the molecule containing DAC as CJC-1295. However, confusion arose as they also offered the peptide without DAC. To clarify, the version containing DAC is now called CJC-1295-DAC, and the one without DAC is referred to as CJC-1295 or CJC-1295-no DAC.
Source: Oxford Academic
Source: Oxford Academic
Improved Muscle Strength and Performance: CJC-1295 stimulates the production of GH, which in turn promotes muscle growth and enhances muscle strength. This makes it an area of interest for athletes and individuals looking to improve their physical performance.
Fat Loss: Higher levels of GH can aid in fat loss. By promoting GH release, CJC-1295 may potentially help reduce body fat.
Better Sleep: Some research suggests that CJC-1295 might improve sleep quality by regulating slow-wave sleep.
Enhanced Skin Health: GH has been linked to skin health. By stimulating GH release, CJC-1295 could improve skin elasticity and reduce wrinkles.
Potential Fertility Benefits: As discussed earlier, preliminary studies suggest that CJC-1295 might play a role in addressing fertility issues in both men and women.
Improved Bone Density: GH plays a significant role in bone health. By stimulating GH release, CJC-1295 may potentially help enhance bone density.
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) known for stimulating the release of growth hormone (GH). According to research, subcutaneous administration of CJC-1295 results in dose-dependent, sustained increases in IGF-I and GH levels in healthy adults. The peptide has been deemed safe based on these studies.
CJC-1295 is typically injected under the skin, often at night, to mimic the body's natural release cycle of growth hormone. When combined with another peptide, Ipamorelin, the body can produce a stronger and more steady release of HGH.
Comprising 30 amino acids, CJC-1295 is recognized as an effective GHRH used for growth. It has been found highly effective for weight loss and muscle building due to its ability to stimulate GH release. Some therapies even combine CJC-1295 with other peptides like Sermorelin and Ipamorelin, aiming to stimulate growth hormone effectively.
CJC-1295 has demonstrated the ability to stimulate and regulate the release of growth hormone (GH) in various studies. A research study on GHRH knockout mice, which inherently lack normal GHRH physiology, revealed that CJC-1295 could effectively restore and maintain regular GH release.
This finding could significantly affect treating abnormal growth conditions across mammalian species, including humans. The pulsatile release of GH, which CJC-1295 helps preserve, is essential for proper secretion of other related hormones. One such hormone is insulin-like growth factor-2 (IGF-1), which is pivotal in promoting normal growth and development.
In essence, the unique properties of CJC-1295 could potentially usher in new therapeutic strategies for dealing with growth disorders.
Research suggests that CJC-1295 may have a role in male fertility. It's been speculated that it could help regulate sperm production, thus potentially enhancing virility. However, these are early findings, and more research is needed to confirm this potential benefit.
In women early research indicates that CJC-1295 might promote ovulation in infertile female patients. However, pregnant women are advised not to use CJC-1295/Ipamorelin because its effects on the baby are unknown.
Moreover, studies have shown a strong link between growth hormone deficiency, low libido, and erectile dysfunction. Given that CJC-1295 stimulates growth hormone release, it's suggested that it could help address these conditions.
Overall, while some evidence suggests a potential role of CJC-1295 in addressing fertility issues, it's important to note that these are preliminary findings.
The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.
Dr. Dominique Bridon holds a Master of Science, Chemical Engineering and Polymer Sciences from Ecole Nationale Supérieure de Chimie and a PhD in Organic Chemistry from the University of Paris XI, ICSN, Orsay, France with Nobel Laureate Sir Derek H. R. Barton as Research Advisor. He completed his Post-Doctoral Research at the University of California, Berkeley. He studied the potential of CJC-1295 as a long lasting GRF analog and also held various leadership positions involving peptide research and technologies at Ipsen, Conjuchem, Redcell, and Abbott Laboratories. Dr. Bridon has served as a Director for Enobia (acquired by Alexion) and Neuronax and as a member of the Scientific Advisory Board of Syntaxin (acquired by Ipsen) and Biosortia. He now brings 30 years of executive and scientific leadership experience to the Epivax Oncology team.
Dr. Dominique Bridon is being referenced as one of the leading scientists involved in the research and development of CJC-1295. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Shop and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Dr. Dominique Bridon is listed in [4] under the referenced citations.
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
Sources:
https://pubmed.ncbi.nlm.nih.gov/16352683/
https://academic.oup.com/jcem/article/91/3/799/2843281
https://pubmed.ncbi.nlm.nih.gov/16822960/
https://www.sciencedirect.com/science/article/abs/pii/S1096637409000409
https://www.nature.com/articles/0803785
https://www.sciencedirect.com/science/article/abs/pii/S1096637409000409
https://journals.physiology.org/doi/abs/10.1152/ajpendo.00201.2006
https://academic.oup.com/endo/article/146/7/3052/2500187?login=false
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