Pentadecapeptide, also known as BPC-157, is an entirely synthetic peptide potentially linked to various cellular functions. Scientists also believe that this peptide has healing properties in experimental models of injuries. Potentially, it could have rejuvenation and recuperation features. New research has emerged that indicates that BPC-157 may regulate inflammation and encourage blood vessel formation.
On the other hand, researchers suggest that TB-500 could help with neurological and brain injuries, as well as the healing processes after injuries. Others indicate that this peptide can assist with hair growth. TB-500 is a man-made variant of the Tβ4, a peptide naturally found within thymus cells, and it appears to modulate cell movement, tissue healing, and differentiation.
Research and Clinical Studies
Currently, clinical research or studies regarding this blend aren’t available. However, we listed a couple of studies that observe the potential actions of individual peptides.
BPC-157 & TB-500 Blend and Tissue Repair
In a study concluded in 1999, rodents were used as models. One-half of the test subjects were presented with saline, while the other half were presented with TB-500 peptide. The main goal of this study was to examine potential tissue repair actions of this peptide. Four days after the experiment, scientists noticed that the group of rodents that received TB-500 showed a 41% increase in epithelial cells. After seven days, the wounds treated with TB-500 had reportedly shrunk by 11% compared to the saline wounds, indicating that TB-500 could potentially be a wound-healing factor.
In another clinical trial conducted in 2006, 72 test subjects with pressure ulcers were presented with TB-500. This study was supposed to examine the potential of thymosin beta 4 in ulcer presence. The test subjects were split into two groups; one group received a placebo for 84 days, while the other group received various peptide concentrations for the same time. After 84 days, there were signs of healing concerning the ulcers.
When it comes to BPC-157, three experimental rodent models were used as subjects, and all were experimentally wounded, either acute or chronic. The rodents were divided into two groups. Again, one group got a placebo, while another group received a BPC-157 peptide. After the experiment ended, a group that received BPC-157 showed a higher number of blood vessels and collagen formed compared to placebo.
BPC-157 & TB-500 Blend and Ligaments
A study in a murine model examined the effect of thymosin beta 4 (TB-500) on MCL healing. Research cut the MCL surgically and treated all the models with a fibrin sealant, and some were further treated with TB-500. The group treated with the peptide had more structured collagen at the four-week time point, with greater collagen cells than the control group. In addition, the mechanical stability of the healing ligament, for instance, the femur-MCL- tibia complex, appeared to be higher in the TB-500 group.
Another investigation examined BPC-157’s therapeutic value in promoting connective tissue repair, particularly tendon healing. The outcome showed that BPC-157 was able to promote tendon cell growth and resistance to oxidative stress, possibly through inducing F-actin assembly, as visualized by FITC-phalloidin staining. The peptide also seemed to increase tendon fibroblast movement in vitro, allowing for migration and dispersal along culture plates. The study further suggested that the FAK-paxillin pathway was implicated in the activity of BPC-157, as Western blot analysis revealed increased phosphorylation of the proteins while overall levels were the same.
BPC-157 & TB-500 Blend and Muscle
A study was conducted on rats with an experimentally injured calf muscle. They were given corticosteroids, which reportedly led to severe muscular damage. Again, they were divided into two groups; one group got a placebo, and the other group got a BPC-157 for up to 14 days.
After the experiment ended, it showed that BPC-157 had helped with a complete repair of their gastric muscles, along with their full ability to function. At the same time, the placebo group didn’t show similar signs.
TB-500 may also have similar effects on muscle cell regeneration on cardiac muscle cells. One study on rodents indicated that TB-500 seems to increase myocardial resilience in conditions of low oxygen, possibly creating an opportunity for cardiac cell repair.
References:
Santra, M., Zhang, Z. G., Yang, J., Santra, S., Santra, S., Chopp, M., & Morris, D. C. (2014). Thymosin β4 up-regulation of microRNA-146a promotes oligodendrocyte differentiation and suppression of the Toll-like proinflammatory pathway. The Journal of biological chemistry, 289(28), 19508–19518. https://doi.org/10.1074/jbc.M113.529966
National Center for Biotechnology Information. “PubChem Compound Summary for CID 132558700, CID 132558700” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/132558700
Maar, K., Hetenyi, R., Maar, S., Faskerti, G., Hanna, D., Lippai, B., Takatsy, A., & Bock-Marquette, I. (2021). Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies. Cells, 10(6), 1343. https://doi.org/10.3390/cells10061343
Pevec D., Novinscak T., Brcic L., Sipos K., Jukic I., Staresinic M., Mise S., Brcic I., Kolenc D., Klicek R., Banic T., Sever M., Kocijan A., Berkopic L., Radic B., Buljat G., Anic T., Zoricic I., Bojanic I., Seiwerth S., Sikiric P. Impact of pentadecapeptide BPC-157 on muscle healing impaired by systemic corticosteroid application. Med Sci Monit. 2010 Mar;16(3):BR81-88. PMID: 20190676. https://pubmed.ncbi.nlm.nih.gov/20190676/
Bock-Marquette, I., Saxena, A., White, M. D., Dimaio, J. M., & Srivastava, D. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466–472. https://doi.org/10.1038/nature03000
Study of Thymosin Beta 4 in Patients With Pressure Ulcers. https://www.clinicaltrials.gov/ct2/show/NCT00382174
Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008 May 15; 453(7193):314-21. doi: 10.1038/nature07039. PMID: 18480812. https://pubmed.ncbi.nlm.nih.gov/18480812/
Seiwerth, S., Milavic, M., Vukojevic, J., Gojkovic, S., Krezic, I., Vuletic, L. B., Pavlov, K. H., Petrovic, A., Sikiric, S., Vranes, H., Prtoric, A., Zizek, H., Durasin, T., Dobric, I., Staresinic, M., Strbe, S., Knezevic, M., Sola, M., Kokot, A., Sever, M., … Sikiric, P. (2021). Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Frontiers in Pharmacology, 12, 627533. https://doi.org/10.3389/fphar.2021.627533
Xu B., Yang M., Li Z., Zhang Y., Jiang Z., Guan S., Jiang D. Thymosin β4 enhances the healing of medial collateral ligament injury in rat. Regul Pept. 2013 Jun 10;184:1-5. doi: 10.1016/j.regpep.2013.03.026. https://pubmed.ncbi.nlm.nih.gov/23523891/
Srivastava, D., Ieda, M., Fu, J., & Qian, L. (2012). Cardiac repair with thymosin β4 and cardiac reprogramming factors. Annals of the New York Academy of Sciences, 1270, 66–72. https://doi.org/10.1111/j.1749-6632.2012.06696.x
Chang, Chung-Hsun et al. “The promoting effect of pentadecapeptide BPC-157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.” Journal of Applied Physiology (Bethesda, Md. : 1985) vol. 110,3 (2011): 774-80. doi:10.1152/japplphysiol.00945.2010. https://pubmed.ncbi.nlm.nih.gov/21030672/
National Center for Biotechnology Information. “PubChem Compound Summary for CID 9941957” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Bpc-157
Sikiric, Predrag et al. “Brain-gut Axis and Pentadecapeptide BPC-157: Theoretical and Practical Implications.” Current Neuropharmacology vol. 14,8 (2016): 857-865. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/#r1
Katherine M. Malinda et.al, Thymosin β4 Accelerates Wound Healing, Journal of Investigative Dermatology, Volume 113, Issue 3, 1999, Pages 364-368, ISSN 0022-202X, https://www.sciencedirect.com/science/article/pii/S0022202X15405950
S Seiwerth, et al. “BPC-157’s effect on healing.” Journal of Physiology, Paris vol. 91,3-5 (1997): 173-8. doi:10.1016/s0928-4257(97)89480-6. https://pubmed.ncbi.nlm.nih.gov/9403790/
Our support team is at your service, ensuring customer satisfaction.
