Adipotide (FTPP) 10mg

What’s Adipotide FTPP Structure?

Adipoptide has a unique structure consisting of the following amino acid sequence - CKGGRAKDC-GG-D(KLAKLAK)2. Most interesting to us is the initial 9 amino acid sequence (CKGGRAKDC) which specifically targets the receptor system found in blood vessels supporting the adipose tissue. 

Not only that, this amino acid sequence is also identified as a vascular marker for the adipose tissue. What this means is that Adipotide induces removal of white fat resulting in rapid obesity reversal and bringing the metabolism back to normal. 

If we focus our attention to the remainder amino acid sequence, more specifically (KLAKLAK)2, we see that it possibly leads to programmed cell death. So, looking at Adipotide as a whole, it’s a peptide that specifically targets and binds to the adipose cells, disrupting their blood flow, and then disrupts their metabolism and leads to the removal of white fat cells. 

Though further research is required, scientists suggest the potential of using this peptide to not only attack white fat cells, but also reduce visceral fat as well as targeting intra-organ fat. 

Adipotide And Fat Loss

We already talked about the Adiptode’s potential in combating obesity and restoring metabolic balance, but we need to be careful talking about it since a lot of the studies performed were done on animal test subjects. 

One such study was done in 2011 on three different species of obese monkeys. Remarkably, after determining the right dosage (based on the specie), a significant and predictable weight loss was achieved in all subjects.

So, why is this drug so significant? Up until this point, the majority of obesity and weight management drug’s mechanism of action was appetite suppression and energy expenditure via nervous system stimulation. By introducing Adipotide, scientists were able to directly regulate the fat tissue through its vasculature, which was a major breakthrough. 

And what were the results? 

The main animal group used were rhesus macaques, which are one of the most relevant primate models for human obesity as they have a history of spontaneous obesity, increased food intake and lack of physical activity. All test subjects were classified as obese with a body mass index ranging from 34 to 45. What’s also interesting about these monkeys (such as us humans), is that they were abundant in abdominal fat… e.i. had fat bellies.

The group was, of course, divided into two:

• Control - in which all the monkeys received saline 
• Test - where Adipotide was administered

At the end of just 9 weeks, subjects in the test group experienced a significant reduction in:

• Body weight - from 1.8 to 2.1kg/4-4.6 lbs, which approximates to 15-20% of their total weight 
• BMI - that dropped by a whopping 17.1-20.4%
• Abdominal circumference - dropped by 13.1-14.2%

On the contrary, the control group experienced no change. 

Adipotide As A Cancer Treatment

Initially, Adipotide was developed as a cancer fighting agent whose aim was to starve cancer cells (in the brain, lungs or kidneys) by blocking the blood vessels. Since cancer cells require vast amounts of blood to be able to grow and metastasize, it is postulated that limiting this blood supply will prevent this growth and eventually lead to their death.

Unfortunately, studies such as these are lacking and we still don’t have enough evidence to evaluate adipotide’s effectiveness. Though most researchers agree Adipotide should be applied in the early stages of cancer, to prevent its growth and spread. We are unsure as to how it would act in more advanced stages of cancer still.

Glucose Tolerance And Blood Sugar Regulation

Glucose level represents the amount of sugar in blood and usually accompanies obese individuals, so Adipotide’s weight loss effect can help with glucose management.

Traditionally, lowering glucose levels was done with exercise and a proper diet but it requires a lot of effort and it’s easy to “fall off the rails.” But with the introduction of a drug such as Adipotide, we can get the patients “back on track,” help with their weight loss journey and give them another tool to ensure proper glucose level regulation.

Of course, claims such as these do require more scientific studies as this peptide’s mechanism of action is not 100% known - does it directly affect the blood glucose levels, or is glucose regulation a “side effect” because the hunger is suppressed and the person just starts eating less.

The Future Of Adipotide

We’ve made a lot of (positive) claims about Adipotide in this article, as this peptide does look promising, especially in the realm of managing weight, diabetes, blood glucose and overall fat in our body.

But the majority of these conclusions were drawn based solely on a handful of studies done up until this point. What we need now is more support and research from the scientific community. We need to do more testing and delve deeper into the Adipotide’s mechanism of action, see what it does to our body, and if there are some side effects we need to be on the lookout for.

Overall, its future does seem bright, but we need more research to ensure its effectiveness!